Last Updated on April 4, 2025 by Analgesia team
Toothaches are the absolute worst, aren’t they? That throbbing, relentless pain that won’t let you sleep, eat, or even think straight. It’s enough to drive anyone up the wall. When you’re in the thick of it, all you want is relief—and fast.
Painkillers are usually the first port of call, but not all are created equal. Some work wonders, while others barely take the edge off. Sound familiar?. If you’re searching for the strongest painkillers for toothache or wondering what to do when “painkillers aren’t working for my toothache,” you’re in the right place.
In this guide, we’ll dive into the most effective over-the-counter and prescription painkillers for a toothache. We’ll also touch on what to do when the pain feels unbearable, including natural remedies that can offer temporary relief. So, grab a cuppa and let’s get you on the road to feeling like yourself again.
Causes of Toothache
Toothache isn’t just annoying—it’s your body’s way of saying something’s not quite right. The pain can range from a mild twinge to a full-blown throbbing nightmare. But what’s behind it? Here are the most common culprits:
Cavities
A cavity is a hole in your tooth caused by decay. It exposes the nerves inside your tooth, making every bite and sip a potential disaster. It’s like your tooth screaming for help.
Gum Disease
Gum inflammation or infection, often due to poor oral hygiene, can lead to tooth pain. As the gums weaken, they pull away from the teeth, leaving roots exposed and vulnerable.
Tooth Infection or Abscess
An untreated cavity or injury can cause bacteria to invade the tooth’s pulp (the sensitive tissue inside). This leads to infection, and sometimes an abscess—a painful pocket of pus that’s not messing around. Trust me, this one needs attention.
Impacted Wisdom Teeth
When wisdom teeth can’t break through the gums properly, they push against surrounding teeth, causing pain and swelling. It’s like overcrowding at a gig—it’s bound to cause chaos.
Cracked or Broken Teeth
Accidents, grinding, or biting down on something super hard can cause cracks in your teeth. If the crack reaches the nerve, it’ll feel like you’re biting into hot lava. This is likely where the strongest painkillers for toothache can come in.
Sinus Pressure
Bet you didn’t think your sinuses could be involved! Sometimes sinus infections can cause pain in your upper teeth, thanks to the pressure on nearby nerves.
Knowing what’s causing the pain is half the battle. Next up, we’ll dive into over-the-counter painkillers that can help you get through it—let’s sort you out.
Over-the-Counter Strongest Painkillers for Toothache
When tooth pain strikes, the first thing most people reach for is over-the-counter painkillers. They’re quick, easy to grab, and can make a world of difference. However, it makes a difference only if you choose the right one. Here are the top options to consider:
Ibuprofen
Known for its anti-inflammatory powers, ibuprofen is often the go-to for toothaches. It not only reduces pain but also helps with swelling, which is common in conditions like gum disease or abscesses. It’s solid for mild to moderate pain, but don’t go over the recommended dose.
Paracetamol
Simple yet effective, paracetamol is a popular choice for easing toothache discomfort. While it doesn’t tackle inflammation, it does a cracking job at reducing pain. Pairing it with ibuprofen can be even more effective for severe cases. However, double-check with a pharmacist first.
Aspirin
A classic pain reliever that can ease toothache pain. However, it’s best avoided if you’re under 16 or prone to stomach issues. It’s strong stuff but has its downsides.
Topical Pain Relief
For quick, targeted relief, you can’t go wrong with a benzocaine-based gel or ointment. These products numb the area on contact and can be a lifesaver for sudden, intense pain. The relief is short-lived, but sometimes that’s all you need.
If these options aren’t cutting it or you’re wondering why my painkillers aren’t working for my toothache, don’t worry—we’ll cover prescription painkillers next to tackle the worst cases. Hang tight.
Prescription Strongest Painkillers for Toothache
Sometimes, over-the-counter options just don’t cut it—especially when the pain is unbearable. That’s when prescription painkillers step in. These heavy hitters are reserved for severe cases and should always be used under medical supervision. Here’s what you need to know:
Co-Codamol: The Dynamic Duo
Co-codamol combines paracetamol with codeine, offering a one-two punch for pain relief. It’s stronger than standard painkillers and can help with an intense toothache. It is regarded as one of the strongest painkillers for toothache. But remember, codeine can be addictive, so only use it as prescribed.
Hydrocodone: The Heavyweight
If you’re dealing with excruciating pain and wondering what is a strong prescription painkiller for a toothache, hydrocodone might be the answer. It’s a powerful opioid that’s highly effective but comes with risks like drowsiness or dependency. It’s only for short-term use under strict medical guidance.
Tramadol: The Steady Relief
Tramadol is another option for severe tooth pain, especially when the pain is persistent and disruptive. It works by altering how your brain perceives pain. This one’s not to be taken lightly—it’s prescription-only for good reason.
While prescription painkillers can be a lifesaver, they’re not a long-term solution. A toothache often signals an underlying problem, such as an infection or abscess, that needs treatment. Painkillers are a temporary fix while you wait to see your dentist. Masking the pain won’t solve the root cause.
If you’re still struggling and thinking, “Painkillers aren’t working for my toothache,” don’t worry. Next, we’ll explore other remedies and tips to stop the worst tooth pain. Let’s keep going.
Alternative Remedies to Stop Tooth Pain
If painkillers aren’t cutting it and you’re wondering, “How do you stop the worst tooth pain?”, don’t despair. There are a few other tricks that can offer relief until you get professional help. While these remedies aren’t a fix for the underlying issue, they can ease the discomfort and make things bearable. Here’s the scoop:
Saltwater Rinse
A simple but effective option, rinsing with warm saltwater can help reduce swelling and kill bacteria. It’s particularly helpful for gum infections or minor irritations. It’s old-school but works like a charm.
Clove Oil
Clove oil contains eugenol, a natural compound with numbing and anti-inflammatory properties. Apply a tiny amount directly to the affected area for quick relief. It’s the MVP of natural remedies.
Cold Compress
If your jaw or cheek is swelling, a cold compress can help reduce inflammation and dull the pain. Wrap some ice in a cloth and hold it against the area for 15 minutes at a time. It won’t fix the tooth, but it’ll ease the misery.
Over-the-Counter Gels
Topical gels with benzocaine can offer temporary relief by numbing the area. Just be sure to follow the instructions on the packaging.
Peppermint Tea Bags
Steep a peppermint tea bag in warm water, let it cool slightly, and place it directly on the aching tooth. The mild numbing effect and anti-inflammatory properties can help soothe pain. A cuppa never hurts, eh?
These remedies can tide you over, but if the pain persists, it’s time to call in the pros. Next, we’ll talk about when to see a dentist—because long-term relief starts there.
When to See a Dentist
Painkillers and remedies can only get you so far. If your toothache keeps coming back or gets worse, it’s time to stop managing the pain and start fixing the problem. This is because masking it won’t solve anything. Here’s when to call your dentist ASAP:
Persistent Pain
If the pain lasts more than a couple of days, it’s likely a sign of something more serious, like an infection or decay that needs treatment.
Swelling or Fever
Swelling around your jaw or cheeks, especially if it’s paired with a fever, could mean you have an abscess. This is an emergency—don’t wait to seek help.
Difficulty Eating or Sleeping
When the pain disrupts your daily life, like making it hard to eat, drink, or sleep, it’s time to see a professional.
Bleeding or Signs of Infection
Bleeding gums, bad breath, or pus near a tooth are all signs of an infection that requires a dentist’s care. Painkillers won’t solve this—they’ll only delay treatment.
Conclusion
Toothache pain can be relentless, but you don’t have to suffer in silence. From over-the-counter options like ibuprofen and paracetamol to prescription painkillers like co-codamol, there are plenty of ways to manage the discomfort. The strongest painkillers for toothache have been unmasked, and you are free to make a choice that works best for you.
But remember, painkillers are just a temporary fix. The real solution lies in addressing the root cause with proper dental care. Whether it’s a cavity, abscess, or impacted tooth, a dentist is your best bet for long-term relief.
So, don’t let the pain win. Try the remedies, take the right painkillers, and if the pain doesn’t let up, book that dentist appointment. You’ve got this—here’s to a pain-free smile!