Sickle Cell Disease Symptoms (Symptoms)

Sickle cell disease (SCD) symptoms vary from person to person. It can be mild or severe but can include:

• Anemia: A low number of red blood cells, which can cause fatigue, dizziness, and shortness of breath. 
• Painful swelling: Also known as dactylitis, this can occur in the hands and feet.
• Jaundice: A yellowing of the skin, eyes, and mouth caused by a buildup of bilirubin from dying red blood cells. 
• Painful episodes: Also known as sickle crises, these can occur suddenly and cause severe pain in the chest, arms, and legs. 
• Acute chest syndrome: A life-threatening condition that occurs when sickle cells block oxygen flow in the lungs. 
• Delayed growth: Children with SCD may experience delayed growth and development. 
• Frequent infections: People with SCD are at a high risk for infection. 
• Priapism. The sickle cells block the blood vessels in the penis, causing great pain. If not treated right away, it can cause erectile dysfunction.

image credit to Kadrmas Eye Care New England

Other complications of SCD include stroke, gallstones, leg ulcers, and kidney problems. 

Sickle cell disease is caused by a genetic mutation in the hemoglobin S gene. Symptoms usually begin in early childhood, around 5 or 6 months of age.