Last Updated on May 4, 2025 by Analgesia team
Arthritis pain can range from mild discomfort to debilitating flare-ups that impact your daily life. Fortunately, there are several types of painkiller tablets and topical treatments available to help manage symptoms effectively. Choosing the right option depends on the type of arthritis you have, how severe the pain is, and other health factors.
There are several types of painkiller tablets that can help manage arthritis pain. Here are some common options:
Over-the-Counter Painkillers
These are typically the first step in managing mild to moderate arthritis pain.
- Paracetamol (Acetaminophen)
Paracetamol is widely used for mild to moderate joint pain. It doesn’t reduce inflammation, but it can relieve everyday aches and stiffness. Generally well tolerated when taken as directed. - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
These help with both pain and inflammation. Common OTC options include:- Ibuprofen (Advil, Nurofen, Motrin IB)
- Naproxen Sodium (Aleve, Feminax Ultra)
NSAIDs are often recommended for conditions like osteoarthritis and rheumatoid arthritis, but long-term use may carry risks for the stomach, kidneys, and heart—especially at higher doses.
Prescription Painkillers
If over-the-counter options don’t provide enough relief, your doctor may recommend:
- Stronger NSAIDs
Prescription versions like diclofenac or celecoxib offer enhanced pain relief for more severe inflammation. - Opioids
Medications like tramadol or codeine may be used for short-term pain control in severe cases. Due to the risk of dependence and side effects, opioids are typically used only when absolutely necessary. - Duloxetine (Cymbalta)
Originally developed as an antidepressant, duloxetine is now also approved for treating chronic musculoskeletal pain. It may be particularly helpful for people with both arthritis and depression or anxiety.
Topical Painkillers
Topical options are useful for targeting pain in specific joints, like the knees or hands, and may carry fewer systemic side effects.
- Capsaicin Cream
Made from chili pepper extract, this cream reduces a substance in the nerves that transmits pain. It’s often effective for osteoarthritis in small joints. - Topical Diclofenac (e.g. Voltarol Gel)
A gel version of NSAIDs that penetrates the skin to reduce inflammation in the affected joint. This option is widely used in the UK for knee and hand arthritis.
Important Considerations
- Always follow dosing instructions and speak with a healthcare provider before starting or combining painkillers.
- Pain relief should be part of a broader arthritis management plan that may include exercise, physical therapy, weight management, and joint protection strategies.
- If you have underlying health conditions such as high blood pressure, kidney problems, or stomach ulcers, your doctor may recommend specific medications or alternatives.
Conclusion
There’s no one-size-fits-all solution for arthritis pain. The best painkiller for you will depend on your symptoms, medical history, and how your body responds. By working with your GP or specialist, you can find a pain relief strategy that improves your comfort and mobility—while minimising risks.