Last Updated on February 22, 2025 by Analgesia team
Pure Red Cell Aplasia & Anaemia
PRCA is a medical abbreviation for pure red cell aplasia, a rare blood disorder that causes anaemia by reducing the bone marrow’s production of red blood cells:
Pure red cell aplasia (PRCA) |
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What it is |
A rare blood disorder that causes anemia by reducing the bone marrow’s production of red blood cells
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Causes |
The causes can be congenital or acquired and may be associated with various underlying causes, such as autoimmune diseases, viral infections, or exposure to certain medications or toxins
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Symptoms |
Defined by persistent anaemia, reticulocytopenia, and a bone marrow devoid of erythroid precursors
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Treatment |
Typically involves immunosuppression, but specific pathogenic subtypes are associated with specific therapeutic approaches
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PRCA can be a complication of major or bidirectional ABO-incompatible allogeneic hematopoietic stem cell transplants (allo-HSCT). It can also be associated with collagen vascular/autoimmune disorders such as systemic lupus erythematosus, lymphoproliferative disorders such as chronic lymphocytic leukaemia or large granular lymphocyte leukaemia, infections, particularly B19 parvovirus, thymoma and other solid tumours.